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Organic Barley Grass Barley Grass extract "green" real TV was introduced.
Astaxanthin is a component of TV is about Asutamaniana. 　　　　　

Doctor of Agriculture Asutamaniana health food supervision


Comfortable awakening in the morning, sleep the night of the1000-fold vitamin E antioxidant power, whitening, stain, wrinkles, sagging improve anti-rust ingredients, anti-aging, fatigue after sports, reduce eye strain in computer, vitamin E 1,000 times the antioxidant power, water-holding capacity, diet, Dr. Wataru Miki Agriculture
The supervision items.

Natural Astaxanthin?

Astaxanthin, a member of the carotenoid family, is recognized as red-orange pigment found in marine and aquatic animals, such as salmon, salmon roe, and red sea bream. The red color of shellfish (e.g., shrimps and crabs), salmon roe, salmon, and the skin of red sea bream is often due to Astaxanthin.

However, Astaxanthin cannot be synthesized by animals and it must be provided in the diet. The seafood such as crabs and salmons mainly take Astaxanthin by eating krills and small pink shrimps that accumulate Astaxanthin in their body by food chain.

Astaxanthin is appreciated for its vivid red-orange color tone and the heat stability and it has been used broadly and industrially to impart the characteristic pink color to seafood such as farmed salmon and sea bream.

Recently, as studies progress, it has been clearly and unequivocally indicated that Astaxanthin's antioxidant properties are superior by 100－1,000 times to that of other commercial carotenoids as well as Vitamin E that does not allow the following antioxidant medicine. Moreover, increasing evidence suggests that Astaxanthin has extremely useful characteristics in scavenging of active oxygen, immunostimulation, cancer prevention and so on.

A demand for natural Astaxanthin is now emerging in the fast－growing health market as materials for functional health food, drinks and anti-aging cosmetics.

Haematococcus Pluvialis
Biogenic cultures algae Haematococcus pluvialis in closed photobioreactor, therefore air pollution and contamination of alien substances can be prevented.

Astaxanthin extracted from Haematococcus pluvialis is published on the Food Additive Status List of Japan [names natural coloring agent (Haematococcus Algae Pigment)](No.372). It has been performed various confirmatory tests for the safety of the Astaxanthin and its safety has been proved.

Astaxanthin, Zinc, Selenium, Damasukurozu the collagen, royal jelly, hyaluronic acid
Most powerful mineral antioxidant! Minerals critical to skin!
Achieve Purupuruo skin! Burugarianrozu blending luxury!
Anti-aging natural products! Fight fatigue and aging


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　１）Antioxidant Propertes

In order to maintain healthy body conditions, it is said that it is effective to take substances to scavenge the excess active oxygen accumulated in our bodies. Carotenoids such as β-carotene and Vitamin E are known to have antioxidant functions.
It has been indicated that Astaxanthin in xanthophylls is much powerful antioxidant than other antioxidant materials.
Although once the in-body oxidation reaction by active oxygen starts, it spreads like a chain reaction. Astaxanthin has a function to inhibit the chain reaction and the harmful effects of active oxygen effectively.
When lipids by active oxygen and oxidized protein occur in cell walls (lipid bilayer structure) that control an important function of life cells, the whole cells will have a serious damage. If the oxygen degeneration occurs in sequences, it leads to the cause for various diseases and poor physical health conditions.
The main factor of the symptoms of aging is the accumulation of the decline of cell functions by oxidation degeneration. By taking powerful antioxidant materials such as Astaxanthin, it is said to be effective in recovering poor physical health conditions, aging prevention and endowment of resistance to diseases.

Kuhn,R., Soerensen, N.A.: The coloring matters of the lobster (Astacus gammars L.), Z. Angew.Chem.,1938,51,465-466

　・Singlet oxygen scavenging activity

Singlet oxygen is typical in the reactive oxygen species. It is said that singlet oxygen has strong toxicity and overexposure of ultra-violet rays causes or accelerates skin cancer development. Various tests or experiments demonstrate the antioxidant properties of Astaxanthin as a quencher of singlet oxygen. The effect is said to be 100 times stronger than Vitamin E (α-tocopherol), typical antioxidant material, and 10 times stronger thanβ-carotene.

(1)幹　渉、山口勝巳、鴻巣章二、日本水産学会春季大会講演要旨集：p.211(1982)
(2)Miki, W: Biological functions and activities of animal carotenoids, Pure & Appl. Chem., Vol.63, No.1,pp. 141-146,1991.
(3)清水延寿・幹　渉： 活性酸素消去活性,海洋生物のカロテノイドー代謝と生物活性,日本水産学会監修, 幹　渉編, 水産学シリーズ94, p97-p104
(4)Di Mascio, P., Devasagayam, T.P., Kaiser, S., Sies, H. : Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers, Biochem. Soc. Trans., 1990, 18, 1054-1056.
(5)Tatｓuzawa, H., Maruyama, T., Misawa, N., Fujimori, K., Nakano, M. : Quenching of singlet oxygen by carotenoids produced in escherichia coli-attenuation of singlet oxygen-mediated bacterial killing by carotenoids., FEBS Lett., 2000, 484, 280-284.


　・Protecting lipids from peroxidation properties

Lipids peroxidation reaction is the oxidation of cell lipids by attacks from active oxygen, and it is said to be one of the causes to accelerate aging. Also, it may cause arteriosclerosis. This reaction likely to occur in cell walls and the cell walls may become oxidized in sequences because lipids peroxidation reaction progresses in a chain reaction. It has been reported by the rat experiment that Astaxanthin's lipids peroxidation properties are superior by 1000 times to that of Vitamin E (α-tocopherol).

(1)Paola Palozza, Norman I. Krinsky: Astaxanthin and canthaxanthin are potent antioxidants in a membrance model, Archives Of Biochemistry and Biophysics., Vol.297, No.2, pp. 291-295, 1992.
(2)幹　渉、藤田孝夫：魚類のカロテノイド代謝,化学と生物,1985,23,640-648
(3)Michi Kurashige, Eiji Okimasu, Masayasu Inoue, Kozo Utsumi: Inhibition of Oxidative Injury of Biological Membranes by Astaxanthin,
(4)清水延寿・幹　渉： 活性酸素消去活性,海洋生物のカロテノイドー代謝と生物活性,日本水産学会監修, 幹　渉編, 水産学シリーズ94, p84
(5)Lim, B.P., Nagao, A., Terao, J., Tanaka, K., Suzuki, T., Takama, K.:Antioxidant activity of xanthophylls on peroxyl radical-mediated phospholipid peroxidation, Biochim. Biophys. Acta, 1992, 1126, 178-184.
(6)Jorgensen, K., Skibsted, L.H. : Carotenoid scavenging of radicals. Effect of carotenoid structure and oxygen partial pressure on antioxidative activity, Z. Lebensm. Unters. Forsch., 1993, 196, 423-429.
(7)Barros, M.P., Pinto, E., Colepicolo, P., Pedersen, M. : Astaxanthin and peridinin inhibit oxidative damage in Fe(2+)-loaded liposomes:scavenging oxyradicals or changing membrane permeability?, Biochem. Biophys. Res. Commun., 2001, 288, 225-232.
(8)Goto, S., Kogure, K., Abe, K., Kimata, Y., Kitahama, K., Yamashita, E., Terada, H. : Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antipreoxidative activity of the carotenoid astaxanthin, Biochim. Biophys. Acta, 2001, 1512, 251-258.
(9)Shibata, A., Kiba, Y., Akati, N., Fukuzawa, K., Terada, H. : Molecular characteristics of astaxanthin and beta-carotene in the phospholipid monolayer and their distributions in the phospholipid bilayer, Chem. Phys. Lipids, 2001, 113, 11-22.

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　２）Enhance Immune System

Astaxanthin has attracted attention for its strong antioxidant properties and many studies have been done for its physiological functions. The study reports suggest that Astaxanthin has potentials to defense bacteria and virus and to enhance immune competence in laboratory mouse experiments.


(1)Harumi Jyonouchi, Sining Sun, Myron D.Gross: Astaxanthin, a carotenoid without vitamin A activity, augments antibody response in cultures including T-helper cell
clones and suboptimal doses of antigen, Biochemical and Molecular Roles of Nutrients, American Institute of Nutrition 2483-2792, 1995(2)Harumi Jyonouchi, Roberta J. Hill, Yoshifumi Tomita, Robert A. Good: Studies of immunomodulating actions of carotenoids. I. Effects of β-Carotene and Astaxanthinon murine lymphocyte functions and cell surface marker expression In Vitro culture system, Nutr Cancer 16, 93-105, 1991
(3)Harumi Jyonouchi, Lei Zhang, Yoshifumi Tomita: Studies of immunomodulatig actions of carotenoids.II. Astaxanthin enhances In Vitro antibody production to
T-dependent antigens without facilitating polyclonal B-cell activation, Nutr Cancer 19, 269-280, 1993



　３）Improve Eyestrain,Muscle Fatiqu, Athletic Capability

Astaxanthin has attracted attention for its strong antioxidant properties and many studies have been done for its physiological functions. The study reports suggest that Astaxanthin has potentials to defense bacteria and virus and to enhance immune competence in laboratory mouse experiments.

(1)Harumi Jyonouchi, Sining Sun, Myron D.Gross: Astaxanthin, a carotenoid without vitamin A activity, augments antibody response in cultures including T-helper cell clones and suboptimal doses of antigen, Biochemical and Molecular Roles of Nutrients, American Institute of Nutrition 2483-2792, 1995
(2)Harumi Jyonouchi, Roberta J. Hill, Yoshifumi Tomita, Robert A. Good: Studies of immunomodulating actions of carotenoids. I. Effects of β-Carotene and Astaxanthin on murine lymphocyte functions and cell surface marker expression In Vitro culture system, Nutr Cancer 16, 93-105, 1991
(3)Harumi Jyonouchi, Lei Zhang, Yoshifumi Tomita: Studies of immunomodulatig actions of carotenoids.II. Astaxanthin enhances In Vitro antibody production to T-dependent antigens without facilitating polyclonal B-cell activation, Nutr Cancer 19, 269-280, 1993
(4)Tomita, Y., Jyonouchi, H., Engelman, R.W., Day, N.K., Good, R.A. : Preventive action of carotenoids on the development of lymphadenopathy and proteinuria in MRL-lpr/lpr mice, Autoimmunity, 1993, 16, 95-102.
(5)Jyonouchi, H., Sun, S., Gross, M. : Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent stimulant and antigen, Nutr. Cancer, 1995, 23, 171-183.
(6)Jyonouchi, H., Sun, S., Mizokami, M., Gross, M.D. : Effects of various carotenoids on cloned, effector-stage T-helper cell activity, Nutr. Cancer, 1996, 26, 313-324.
(7)Bennedsen, M., Wang, X., Willen, R., Wadstroem, T., Andersen, L.P. : Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes, Immun. Letters, 1999, 70, 185-189.
(8)Mahmoud, F.F., Haines, D.D., Abul, H.T., Abal, A.T., Onadeko, B.O., Wise, J.A. : In vitro effects of astaxanthin combined with ginkgolide B on T lymphocyte activation in peripheral blood mononuclear cells from asthmatic subjects, J Pharmacol Sci., 2004, 94, 129-136.



　４）Inhibit Skin Aging (skin-whitening effect)

As everybody knows, strong sunlight causes skin flecks and wrinkles and accelerates skin aging. The exposure to ultra violet rays produce active oxygen in skin is thought to be the direct cause of the skin flecks and wrinkles. Study reports show the positive effects of Astaxanthin, such as protection from sunburn, wrinkles made by inhabitation of melanin formation, improvement of resilience and decrease of skin wrinkles by adding Astaxanthin in the external medicine for skin.

(1)関　太輔、末木博彦、河野弘美、菅沼　薫、山下栄次：ヘマトコッカス由来アスタキサンチンの皮膚に及ぼす影響―ヒト皮膚刺激試験・反復塗布試験・目尻シワ取り効果、Fragrance Journal,29,98-103,2001
(2)山下栄次：オキアミ由来アスタキサンチンの色素沈着抑制効果、Fragrance Journal,14,180-185,1995
(3)Irene O'Connor, Nora O'Brien: Modulation of UVA light-induced oxidative stress by β-carotene, lutein and astaxanthin in cultured fibroblasts, Journal of Dermatological Science 16,226-230,1998
(4)Savoure, N., Briand, G., Amory-Touz, M.C., Combre, A., Maudet, M., Nicol, M. : Vitamin A status and ｍetabolism of cutaneous polyamines in the hairless mouse after UV irradiation: Action of β-carotene and astaxanthin, Int. J. Vitam. Nutr. Res., 1995, 65, 79-86.
(5)Bohm, F., Edge, R., Lange, L., Truscott, T.G. : Enhanced protection of human cells against ultravioletlight by antioxidant combinations involving dietary carotenoids, J. Photochem. Photobiol. B, 1998, 44, 211-215.
(6)Lyons, NM., O'Brien, NM. : Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture, J. Dermatol. Sci., 2002, 30, 73.
(7)Stahl, W., Heinrich, U., Jungmann, H., Sies, H., Tronnier, H. : Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans, Am. J. Clin. Nutr., 2000, 71, 795-798.
(8)Lee, J., Jiang, S., Levine, N., Watoson, R.R. : Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure, Proc. Soc. Exp. Biol. Med., 2000, 223, 170-174.



　５）Inhibit and Prevent Diabetic Syndrome

In vivo and in vitro experiments report the anti-inflammatory properties of Astaxanthin.